According to statistics, headaches affect 12 to 16% of Europeans, and at least five million Spaniards.

Obviously, in many cases, headache occurs due to excess histamine in the circle. We know from histamine that it plays a very important role in the local immune response and also as a neurotransmitter. It is a very well known substance among allergy sufferers and is responsible for the irritating side effects of inflammation. In addition, headache is responsible for the transfer of innumerable physiological functions associated with inflammation. Below you can see a summary of the symptoms mediated by histamine (click on the photo to enlarge).

High histamine levels may be due to poor metabolism due to a lack of two enzymes, diamine oxidase (DAO) and histamine N-methyltransferase (HNMT).

We can find the reasons for the failure of these enzymes in genetic, pharmacological or pathological factors.

In addition to genetics, it has been estimated that about 20% of the population is taking drugs that inhibit DAO:

• Analgesics
• Antihistamines
• Antidepressants
• Antihypertensive drugs
• Antirheumatic drugs
• Antiseptics
• Anti-TB drugs
• Bronchiolitics
• Cardiotonics

Or take an endogenous histamine-releasing drug:

• Analgesics
• Anesthetics
• Antitussives
• Cytostatic
• Expectorants
• Mucolytics
• Muscle relaxants
• Anti-inflammatory

Pathological factors are the ones that interest us the most, because we can change them by acting in accordance with our diet. This aspect depends on intestinal inflammatory processes. Nothing New Under the Sun, virtually all paleo practitioners know that gut health is at the core of our health. We already know that grains and legumes provoke and intensify inflammation and disrupt the balance of the intestinal epithelium. But there are also paleo “legal” foods that can increase histamine levels or inhibit its metabolism.

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Foods containing moderate amounts of histamine:

Tomato, spinach, eggplant

• Avocado
• Citrus, banana, pear, kiwi, strawberry, red plum, raspberry.
• Canned vegetables and vegetables.
• Wheat (no paleo)
• Sauerkraut
• Orange, lemon, banana, pineapple, industrial strawberry juice.
  • Beer and red wine (not paleo)
  • Yeast, baked goods and pastries (not paleo)
  • Tea
  • Chocolate, marzipan, nougat. (not paleo)
  • Preservatives and flavors in fried and sweet potatoes, colors. (not paleo)
  • Wine vinegar
  • Nuts, walnuts, cashews, peanuts.
  • Peanuts (not paleo)

Foods that secrete histamine or contain other substances that delay the clearance of histamine:

• Tomatoes (not paleo)
• Strawberries, raspberries.
• Citrus
• Tropical pineapple
• Papaya
• Banana
• Plum
• Pear
• Pepper
• Mushrooms
• Wheat germ, buckwheat (not paleo)
• Nuts, especially nuts.
• Cocoa (even if it is pure)
• Egg white
• Additives: glutamate, benzoate, dyes, nitrite, sulfite.

Diamine oxidase blockers (DAO):

• Alcohol
• Cocoa (theobromine)
• Tea
• Energy drinks (with theobromine)

Histamine Supplements:

• Dyes: tartrazine (E 102), yellow 5 (E-102), Sunset Yellow (E 110), azorubin (E 122), amaranth (E 123), cochineal red A (E 124), erythrosine (E 127)
• Preservatives: ascorbic acid and salts (E 200-203), benzoic acid and salts (E 210-213), PHB ester (E 220-227), diphenyl and orthophenyl (E 231-232), sulfite, metabisulfite sodium (E 223)
• Others: nitrates (E 251-252), glutamate (E 620-625)
• Acidity regulators: (di-, tri- and polyphosphates)
• Antioxidants: butylhydroxyanisole (BHA), β-hydroxytoluene (BHT).

Something That May Help

For the metabolism of histamine, we can use hot spices, although they are not recommended in Paleo due to their capsiazin content. But nothing will happen if it is done on time.

The add-on will also help with:

• vitamin B12-B6-B1.
• vitamin C

On the other hand, if you are identifying yourself by many of the symptoms shown in the diagram above, you would better consult your doctor and have a test done, you may have a significant deficiency in enzymes that metabolize histamine.